The UN's refugee agency says. More than three million Syrians are now registered as refugees and the desperate crisis is only getting worse. The UNHCR says Syria is now "the biggest humanitarian emergency of our era" with almost half of all Syrians forced to flee their homes. The majority of refugees have fled to countries neighbouring Syria, with most now seeking shelter in Lebanon. More than 190,000 have been killed in Syria's three-year civil war. Opposition groups in Syria have been fighting forces loyal to President Bashar al-Assad since his government violently suppressed protests against his rule in March 2011. The situation has been worsened in recent months by the formation and advance of the Islamic State group, which now controls large swathes of Syria and Iraq.
researchers say Genetic studies of some of the earliest Ebola cases in Sierra Leone reveal more than 300 genetic changes in the virus as it leapt from person to person, changes that could blunt the effectiveness of diagnostic tests and experimental treatments now in development. The findings, published in Science, suggest the virus is mutating quickly and in ways that could affect current diagnostics and future vaccines and treatments, such as GlaxoSmithKline's Ebola vaccine, which was just fast-tracked to begin clinical trials, or the antibody drug ZMapp, being developed by California biotech Mapp Biopharmaceutical. The findings come as the World Health Organisation said that the epidemic could infect more than 20 000 people and spread to more countries.
At least 18 people have been killed and 13 others are unaccounted for in landslides that struck Japan's Hiroshima prefecture. The landslides that happened in a residential area on the outskirts of Hiroshima city were triggered after the equivalent of a month's rain fell in the 24 hours up to Wednesday morning. Images from the scene showed houses buried in mud and rocks, as rescue teams worked their way towards homes. Prime Minister Shinzo Abe said he had asked local officials to "raise the number of [military] personnel to several hundred in order to strengthen rescue operations". Weather officials have warned, more rain could trigger further landslides.
An Israeli air strike on a house in Gaza has killed three senior Hamas military commanders as Israel vowed to continue its campaign. Hamas told media, Mohammed Abu Shamala, Mohammed Barhoum and Raed al-Attar died in the air strike near the southern town of Rafah. Palestinian rescue services said, they were among six people killed. Hostilities resumed on Tuesday, with each side blaming the other for the collapse of peace talks in Cairo. Israeli Prime Minister Benjamin Netanyahu has vowed to continue the campaign against Gaza militants until "full security and quiet" are achieved for Israeli citizens. Six weeks of fierce fighting have left at least 2,103 people dead, all but 67 of them Palestinians and most of them said to be civilians.
Liberia has imposed a night-time curfew and has quarantined an area of the capital Monrovia in a bid to halt the deadly Ebola outbreak. President Ellen Johnson Sirleaf said the curfew would be from 9 PM local time to 06:00 adding that all movement would be blocked in and out of the West Point area. In a radio broadcast, President Sirleaf blamed her government's failure to bring Ebola under control on the public's disregard for health workers advice and disrespect for official warnings. Liberia already imposed a state of emergency earlier this month, but the number of deaths from the disease has continued to climb. Since the beginning of the year, 1,229 people have died of the virus in Guinea, Liberia, Sierra Leone and Nigeria.